The Cruciatus Curse is one of the three Unforgivable Curses, and its use on a human is punishable by a life sentence in Azkaban. It is a signature spell of Lord Voldemort and his Death Eaters.
The Cruciatus Curse is a piece of advanced Dark Magic that requires more than just the incantation to work effectively. As Bellatrix Lestrange explained to Harry, the caster must possess a genuine and sadistic desire to cause pain for the curse to function at full power. Righteous anger or a desire for retribution is insufficient to produce the curse's full, excruciating effect. There is no known counter-curse for the Cruciatus Curse. The only known defences are to dodge the spell, take cover behind a solid object, or interrupt the caster before they can complete it. A person with exceptional willpower might be able to endure the pain for a short time, but prolonged exposure is devastating.
The incantation, Crucio, is a Latin word meaning “I torture” or “I torment.” It is derived from the Latin crux, meaning “cross,” which was historically an instrument of torture. The English word “excruciating,” which perfectly describes the pain caused by the curse, shares the same root.